Metzger B E, Unger R H, Freinkel N
Metabolism. 1977 Feb;26(2):151-6. doi: 10.1016/0026-0495(77)90050-6.
Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a "mixed meal" containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30-40 of gestation and again 6--8 wk postpartum. The "mixed meal" elicited greater and more prolonged increases in plasma glucose anterpartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is "facilitated" during late human pregnancy.
研究了孕期对摄入含碳水化合物（50克）、蛋白质（25克）和脂肪（10克）的“混合餐”后循环葡萄糖、氨基酸、胰岛素和胰高血糖素变化的影响。对9名受试者在妊娠30 - 40周期间进行了测试，并在产后6 - 8周再次测试。“混合餐”在产前引起血浆葡萄糖更大且更持久的升高，而总血清氨基酸在所有时间点的增加均减弱。面对更大的血糖刺激但较小的生氨刺激，产前血浆胰岛素的综合增加比产后高60%，而胰高血糖素的增加没有显著变化。因此，产前研究期间胰岛素/胰高血糖素的综合反应增加。混合营养物质引起的饮食刺激后胰岛素占优势，这表明在人类妊娠后期摄入氨基酸的合成代谢得到“促进”。
