Rogan M T, Marshall I, Reid G D, Macpherson C N, Craig P S
Department of Biological Sciences, University of Salford, UK.
Parasitology. 1993 Jun;106 ( Pt 5):511-7. doi: 10.1017/s0031182000076812.
Nine vervet monkeys and nine baboons were infected with eggs of Echinococcus granulosus per os. Six of the vervets and one of the baboons possessed hydatid cysts at autopsy, 15-28 months post-infection. The sequential IgG response to hydatid fluid and protoscolex antigens showed considerable inter-animal variation. Infected vervets and baboons became seropositive after an average of 8 months post-infection. Considerable fluctuation in the IgG response was observed, particularly to the hydatid fluid antigen which, in humans, may contribute to the existence of a significant proportion of seronegative individuals. Vervets, in particular, may be useful to study immunological events associated with exposure, development and resolution of hydatid disease in outbred human populations.
九只绿猴和九只狒狒经口感染了细粒棘球绦虫虫卵。在感染后15 - 28个月进行尸检时，六只绿猴和一只狒狒体内有棘球蚴囊肿。对棘球蚴液和原头节抗原的连续IgG反应显示出相当大的动物间差异。感染的绿猴和狒狒在感染后平均8个月血清呈阳性。观察到IgG反应有相当大的波动，特别是对棘球蚴液抗原的反应，在人类中，这可能导致相当比例的血清阴性个体的存在。特别是绿猴，可能有助于研究与非近亲繁殖人群中棘球蚴病的暴露、发展和消退相关的免疫事件。
