T4噬菌体编码的RNA聚合酶亚基阻断宿主转录并使宿主染色体解折叠。
T4 Bacteriophage-coded RNA polymerase subunit blocks host transcription and unfolds the host chromosome.
作者信息
Sirotkin K, Wei J, Snyder L
出版信息
Nature. 1977 Jan 6;265(5589):28-32. doi: 10.1038/265028a0.
DOI:10.1038/265028a0
PMID:834238
Abstract
T4 bacteriophage mutants selected for their ability to grow with cytosine in their DNA are defective in host transcriptional shutoff and host chromosome unfolding. The host RNA polymerase purifed from cells infected by such a mutant lacks a small T4-coded subunit.
摘要
因能在DNA中含有胞嘧啶的情况下生长而被选择出来的T4噬菌体突变体，在宿主转录关闭和宿主染色体解折叠方面存在缺陷。从被这种突变体感染的细胞中纯化得到的宿主RNA聚合酶缺少一个由T4编码的小亚基。
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