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T4噬菌体编码的RNA聚合酶亚基阻断宿主转录并使宿主染色体解折叠。

T4 Bacteriophage-coded RNA polymerase subunit blocks host transcription and unfolds the host chromosome.

作者信息

Sirotkin K, Wei J, Snyder L

出版信息

Nature. 1977 Jan 6;265(5589):28-32. doi: 10.1038/265028a0.

DOI:10.1038/265028a0
PMID:834238
Abstract

T4 bacteriophage mutants selected for their ability to grow with cytosine in their DNA are defective in host transcriptional shutoff and host chromosome unfolding. The host RNA polymerase purifed from cells infected by such a mutant lacks a small T4-coded subunit.

摘要

因能在DNA中含有胞嘧啶的情况下生长而被选择出来的T4噬菌体突变体,在宿主转录关闭和宿主染色体解折叠方面存在缺陷。从被这种突变体感染的细胞中纯化得到的宿主RNA聚合酶缺少一个由T4编码的小亚基。

相似文献

1
T4 Bacteriophage-coded RNA polymerase subunit blocks host transcription and unfolds the host chromosome.T4噬菌体编码的RNA聚合酶亚基阻断宿主转录并使宿主染色体解折叠。
Nature. 1977 Jan 6;265(5589):28-32. doi: 10.1038/265028a0.
2
Change in RNA polymerase associated with the shutoff of host transcription by T4.与T4导致宿主转录关闭相关的RNA聚合酶的变化。
Nat New Biol. 1973 May 30;243(126):131-4. doi: 10.1038/newbio243131a0.
3
The expression of bacteriophage T4 early genes. II. Roles of the beta' subunit of RNA polymerase and termination factor rho of the host in the expression of T4 early genes.噬菌体T4早期基因的表达。II. 宿主RNA聚合酶β'亚基和终止因子rho在T4早期基因表达中的作用。
J Biochem. 1978 Oct;84(4):873-9. doi: 10.1093/oxfordjournals.jbchem.a132199.
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Slow switchover from host RNA synthesis to bacteriophage RNA synthesis after infection of Escherichia coli with a T4 mutant defective in the bacteriophage T4-induced unfolding of the host nucleoid.在用噬菌体T4诱导的宿主类核解折叠存在缺陷的T4突变体感染大肠杆菌后,从宿主RNA合成到噬菌体RNA合成的缓慢转换。
J Virol. 1977 Dec;24(3):775-85. doi: 10.1128/JVI.24.3.775-785.1977.
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Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase.缺乏大肠杆菌RNA聚合酶改变和修饰功能的噬菌体T4突变体。
J Mol Biol. 1974 Dec 25;90(4):739-50. doi: 10.1016/0022-2836(74)90537-3.
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Shutoff of host RNA synthesis in bacteriophage T4-infected Escherichia coli in the absence of host DNA degradation and nuclear disruption.在没有宿主DNA降解和细胞核破坏的情况下,噬菌体T4感染的大肠杆菌中宿主RNA合成的关闭。
J Virol. 1977 Mar;21(3):1240-2. doi: 10.1128/JVI.21.3.1240-1242.1977.
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A gene of bacteriophage T4 whose product prevents true late transcription on cytosine-containing T4 DNA.噬菌体T4的一个基因,其产物可阻止含胞嘧啶的T4 DNA上的真正晚期转录。
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3098-102. doi: 10.1073/pnas.73.9.3098.
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Regulation of RNA metabolism of T7 and related phages.T7及相关噬菌体的RNA代谢调控
Annu Rev Genet. 1972;6:191-202. doi: 10.1146/annurev.ge.06.120172.001203.
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Control of gene expression in bacteriophage T7: transcriptional controls.噬菌体T7中的基因表达调控:转录调控
Mol Gen Genet. 1974;134(4):281-97. doi: 10.1007/BF00337463.
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Transcription of bacteriophage T4 DNA in vitro: selective initiation with dinucleotides.
Eur J Biochem. 1978 Jul 17;88(1):109-17. doi: 10.1111/j.1432-1033.1978.tb12427.x.

引用本文的文献

1
Bacteriophage T4 genome.噬菌体T4基因组。
Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. doi: 10.1128/MMBR.67.1.86-156.2003.
2
Bacteriophage T4 alc gene product: general inhibitor of transcription from cytosine-containing DNA.噬菌体T4 alc基因产物:含胞嘧啶DNA转录的通用抑制剂。
J Virol. 1981 Dec;40(3):822-9. doi: 10.1128/JVI.40.3.822-829.1981.
3
Mapping of two transcription mutations (tlnI and tlnII) conferring thiolutin resistance, adjacent to dnaZ and rho in Escherichia coli.在大肠杆菌中,与dnaZ和rho相邻的赋予硫藤黄素抗性的两个转录突变(tlnI和tlnII)的定位。
Mol Gen Genet. 1980;180(3):609-15. doi: 10.1007/BF00268068.
4
Shutoff of lambda gene expression by bacteriophage T4: role of the T4 alc gene.噬菌体T4对λ基因表达的关闭:T4 alc基因的作用
J Virol. 1980 Jul;35(1):194-202. doi: 10.1128/JVI.35.1.194-202.1980.
5
Sequence and cloning of bacteriophage T4 gene 63 encoding RNA ligase and tail fibre attachment activities.编码RNA连接酶和尾丝附着活性的噬菌体T4基因63的序列分析与克隆
EMBO J. 1984 Feb;3(2):397-402. doi: 10.1002/j.1460-2075.1984.tb01819.x.
6
Correlation between genetic map and map of cleavage sites for sequence-specific endonucleases SalI, KpnI, BglI, and BamHI in bacteriophage T4 cytosine-containing DNA.噬菌体T4含胞嘧啶DNA中遗传图谱与序列特异性内切酶SalI、KpnI、BglI和BamHI切割位点图谱之间的相关性。
J Virol. 1980 Oct;36(1):1-17. doi: 10.1128/JVI.36.1.1-17.1980.
7
Plasmid pR386 renders Escherichia coli cells restrictive to the growth of bacteriophage T4 unf mutants.质粒pR386使大肠杆菌细胞对噬菌体T4 unf突变体的生长具有限制作用。
J Virol. 1982 Jan;41(1):330-3. doi: 10.1128/JVI.41.1.330-333.1982.
8
The bacteriophage T4 regulatory protein gpunf/alc binds to DNA in the absence of RNA polymerase.噬菌体T4调控蛋白gpunf/alc在没有RNA聚合酶的情况下与DNA结合。
J Virol. 1986 Dec;60(3):1145-7. doi: 10.1128/JVI.60.3.1145-1147.1986.
9
Molecular proof that bacteriophage T4 alc and unf genes are the same gene.噬菌体T4 alc和unf基因是同一基因的分子证据。
J Bacteriol. 1986 Nov;168(2):833-8. doi: 10.1128/jb.168.2.833-838.1986.
10
Escherichia coli mutations that prevent the action of the T4 unf/alc protein map in an RNA polymerase gene.阻止T4 unf/alc蛋白发挥作用的大肠杆菌突变位于一个RNA聚合酶基因中。
Genetics. 1988 Feb;118(2):173-80. doi: 10.1093/genetics/118.2.173.