Kaufman L N, Li H Y, Peterson M M, Gilardy A K
Department of Physiology, Michigan State University, East Lansing 48824.
Am J Physiol. 1993 Jul;265(1 Pt 2):R1-6. doi: 10.1152/ajpregu.1993.265.1.R1.
Male Sprague-Dawley rats fed either a high-fat or glucose-enriched diet for 10 wk developed higher blood pressure (BP) and higher urinary catecholamine excretion than rats fed a control diet. After 10 wk of diet treatment, systolic BP was 164 +/- 3, 156 +/- 2, and 145 +/- 4 mmHg in rats fed the high-fat, glucose, and control diets, respectively (P < 0.02 vs. control). During weeks 7-9 of diet treatment, excretion of epinephrine and norepinephrine was increased in hypertensive rats (those fed the high-fat or glucose diet) when compared with rats fed the control diet (P < 0.001). The purpose of this study was to determine whether the hypertensive response to nutrients could be prevented by prior surgical removal of the adrenal medulla. Adrenal demedullation nearly abolished epinephrine excretion, attenuated norepinephrine excretion, and completely blocked the hypertensive response to dietary fat and glucose. These findings suggest that adrenal medullary catecholamines play a role in the hypertensive response to nutrients.
给雄性斯普拉格-道利大鼠喂食高脂或高糖饮食10周后，与喂食对照饮食的大鼠相比，它们的血压（BP）更高，尿儿茶酚胺排泄量也更高。饮食治疗10周后，喂食高脂、高糖和对照饮食的大鼠收缩压分别为164±3、156±2和145±4 mmHg（与对照组相比，P<0.02）。在饮食治疗的第7至9周期间，与喂食对照饮食的大鼠相比，高血压大鼠（喂食高脂或高糖饮食的大鼠）的肾上腺素和去甲肾上腺素排泄增加（P<0.001）。本研究的目的是确定通过事先手术切除肾上腺髓质是否可以预防对营养素的高血压反应。肾上腺髓质切除术几乎消除了肾上腺素排泄，减弱了去甲肾上腺素排泄，并完全阻断了对饮食脂肪和葡萄糖的高血压反应。这些发现表明，肾上腺髓质儿茶酚胺在对营养素的高血压反应中起作用。
