Díez-Itza I, Sánchez L M, Allende M T, Vizoso F, Ruibal A, López-Otín C
Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Spain.
Eur J Cancer. 1993;29A(9):1256-60. doi: 10.1016/0959-8049(93)90068-q.
Zn-alpha 2-glycoprotein (Zn-alpha 2-gp), a protein present at high levels in breast cyst fluid, has been measured in 104 breast tumour cytosols by using an immunoenzymatic assay. Concentrations of Zn-alpha 2-gp ranged from 0 to 23.5 micrograms/mg of total soluble protein, with an average value of 2.4 micrograms/mg. There was no significant correlation between Zn-alpha 2-gp and menopausal status, tumour size or lymph node involvement, or between this protein and biochemical parameters such as oestrogen receptor, cathepsin D or pS2 levels. However, there was a significant association between Zn-alpha 2-gp and histological grade of tumours, with higher Zn-alpha 2-gp levels in well-differentiated tumours (mean 4.6 micrograms/mg) than in moderately (1.8 micrograms/mg) or poorly (0.9 micrograms/mg) differentiated tumours. On the basis of these results, we propose that Zn-alpha 2-gp may be considered as a biochemical marker of differentiation in breast cancer.
锌α2糖蛋白（Zn-α2-gp）是一种在乳腺囊肿液中高表达的蛋白质，本研究采用免疫酶法对104例乳腺肿瘤细胞溶胶中的该蛋白进行了检测。Zn-α2-gp的浓度范围为0至23.5微克/毫克总可溶性蛋白，平均值为2.4微克/毫克。Zn-α2-gp与绝经状态、肿瘤大小或淋巴结受累情况之间无显著相关性，该蛋白与雌激素受体、组织蛋白酶D或pS2水平等生化参数之间也无显著相关性。然而，Zn-α2-gp与肿瘤的组织学分级之间存在显著关联，高分化肿瘤（平均4.6微克/毫克）中的Zn-α2-gp水平高于中分化（1.8微克/毫克）或低分化（0.9微克/毫克）肿瘤。基于这些结果，我们认为Zn-α2-gp可被视为乳腺癌分化的生化标志物。
