Caraceni A, Martini C, Belli F, Mascheroni L, Rivoltini L, Arienti F, Cascinelli N
Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy.
Eur J Cancer. 1993;29A(9):1266-9. doi: 10.1016/0959-8049(93)90070-v.
Neuropsychiatric disturbances may occur following interleukin-2 (IL2) administration. We studied the effects of IL2 infusion on cerebral functions in 7 patients with neuropsychological tests and event-related evoked potentials (P300). We observed a failure in the cognitive performances, an increase in latency, and a decrease in amplitude of P300. These effects followed IL2 administration and were reversible.
白细胞介素-2（IL2）给药后可能会出现神经精神障碍。我们通过神经心理学测试和事件相关诱发电位（P300）研究了7例患者输注IL2对脑功能的影响。我们观察到认知能力下降、潜伏期延长和P300波幅降低。这些影响在IL2给药后出现且是可逆的。
