对S抗原的自身免疫在富克斯异色性睫状体炎中起作用吗？
Does autoimmunity to S-antigen play a role in Fuchs' heterochromic cyclitis?
作者信息
La Hey E, Broersma L, van der Gaag R, Baarsma G S, Rothova A, Kijlstra A
机构信息
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
出版信息
Br J Ophthalmol. 1993 Jul;77(7):436-9. doi: 10.1136/bjo.77.7.436.
Autoimmunity directed against retinal or choroidal antigens has been suggested to play a role in the chorioretinal lesions observed in patients with Fuchs' heterochromic cyclitis. This hypothesis was addressed and patients with Fuchs' heterochromic cyclitis were tested for cellular immunity (migration inhibitory factor assay) against human retinal S-antigen. A significantly higher percentage of patients with Fuchs' heterochromic cyclitis had a positive cellular autoimmune response to S-antigen than healthy controls and other patients with anterior uveitis. This finding is remarkable since Fuchs' heterochromic cyclitis is generally classified as an anterior uveitis and patients with Fuchs' heterochromic cyclitis without chorioretinal lesions also had a positive test. In view of these results and a sensitisation against a corneal antigen reported earlier in Fuchs' heterochromic cyclitis, it is suggested that a chronic low grade grade anterior uveitis or chorioretinitis of unknown origin may cause the release of potent autoantigens in these patients.
针对视网膜或脉络膜抗原的自身免疫被认为在富克斯异色性睫状体炎患者中观察到的脉络膜视网膜病变中起作用。对这一假设进行了研究，并对富克斯异色性睫状体炎患者进行了针对人视网膜S抗原的细胞免疫检测（迁移抑制因子测定）。与健康对照和其他前葡萄膜炎患者相比，富克斯异色性睫状体炎患者对S抗原产生阳性细胞自身免疫反应的比例显著更高。这一发现很显著，因为富克斯异色性睫状体炎通常被归类为前葡萄膜炎，而且没有脉络膜视网膜病变的富克斯异色性睫状体炎患者检测结果也呈阳性。鉴于这些结果以及之前报道的富克斯异色性睫状体炎患者对角膜抗原的致敏情况，有人提出，不明原因的慢性轻度前葡萄膜炎或脉络膜视网膜炎可能导致这些患者释放强效自身抗原。
Zotero 插件