Dodds L, Marrett L D, Tomkins D J, Green B, Sherman G
University of Toronto, Department of Preventive Medicine and Biostatistics, Ontario, Canada.
BMJ. 1993 Jul 17;307(6897):164-8. doi: 10.1136/bmj.307.6897.164.
To determine whether the offspring of cancer survivors are at an increased risk of congenital anomalies and whether cancer therapy before conception is associated with such an increase.
Case-control study using computerised record linkage.
Ontario, Canada.
Parents of children born during April 1979 to December 1986 who had a congenital anomaly diagnosed within the first year of life (45,200 mothers and 41,158 fathers) and a matched sample of parents whose children did not have a congenital anomaly (45,200 mothers and 41,158 fathers).
Cancer diagnosed in either parent before conception and radiotherapy to the pelvis or abdomen or chemotherapy with an alkylating agent.
Among the mothers, 54 cases and 52 controls were identified as having had cancer diagnosed in Ontario (relative risk = 1.04, 95% confidence interval 0.7 to 1.5) and among the fathers, 61 cases and 65 controls were identified (0.9, 0.7 to 1.4). No significant associations were found between congenital anomalies in the offspring and any type of cancer treatment in either the mothers or the fathers.
The risk of congenital anomalies among liveborn offspring whose parents have had cancer or been treated for cancer is not higher than that in the general population.
确定癌症幸存者的后代患先天性异常的风险是否增加，以及受孕前的癌症治疗是否与此种增加有关。
采用计算机化记录链接的病例对照研究。
加拿大安大略省。
1979年4月至1986年12月出生的儿童的父母，这些儿童在出生后第一年内被诊断患有先天性异常（母亲45200名，父亲41158名），以及子女没有先天性异常的父母的匹配样本（母亲45200名，父亲41158名）。
受孕前父母任何一方被诊断患有癌症，以及盆腔或腹部放疗或使用烷化剂化疗。
在母亲中，54例病例和52例对照被确定在安大略省被诊断患有癌症（相对风险=1.04，95%置信区间0.7至1.5），在父亲中，61例病例和65例对照被确定（0.9，0.7至1.4）。在后代先天性异常与母亲或父亲的任何类型癌症治疗之间未发现显著关联。
父母患有癌症或接受过癌症治疗的活产后代患先天性异常的风险并不高于一般人群。
