Tohdo H, Haruma K, Kitadai Y, Yoshihara M, Shimamoto T, Sumii K, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Dig Dis Sci. 1993 Aug;38(8):1422-5. doi: 10.1007/BF01308598.
Bezoars are conglomerates of undigested material in the stomach. Previous reports have shown that a decrease in secretion of pepsin and gastric acid and a delay in gastric emptying might contribute to their formation. To clarify the pathogenesis of the formation of gastric bezoars, we studied gastric emptying in five patients who presented with a bezoar. In addition, gastric acid secretion was studied in three of the cases. Gastric emptying was not delayed in any case, and there was no trend toward a decrease in gastric acid secretion. The five patients were successfully treated by the endoscopic fragmentation and enzymatic dissolution of the bezoars. We conclude that, in Japanese, factors other than a delay in gastric emptying are the main contributors to bezoar formation.
胃石是胃内未消化物质的聚集体。既往报道显示，胃蛋白酶和胃酸分泌减少以及胃排空延迟可能促使胃石形成。为阐明胃石形成的发病机制，我们对5例胃石患者的胃排空情况进行了研究。此外，还对其中3例患者的胃酸分泌情况进行了研究。所有病例的胃排空均未延迟，胃酸分泌也没有减少的趋势。这5例患者均通过内镜下胃石破碎及酶解成功治愈。我们得出结论，在日本人中，胃排空延迟以外的因素是胃石形成的主要原因。
