Araki S, Yokoyama K, Murata K
Department of Public Health, Faculty of Medicine, University of Tokyo, Japan.
Environ Res. 1993 Aug;62(2):325-32. doi: 10.1006/enrs.1993.1117.
To assess the effects of occupational and environmental factors on all faster and slower large myelinated peripheral nerve fibers, we measured the distribution of nerve conduction velocities (DCV) in men exposed to local vibration, lead, thallium, styrene, mixed solvents, and alcohol as well as in diabetic patients. The results indicated that conduction velocities of faster large myelinated nerve fibers are more sensitive to most toxic chemicals and physical factors than those of the slower fibers. Further studies are needed to investigate which of the DCV and the conventional peripheral nerve conduction velocity is a more sensitive indicator of the subclinical effects of these factors and whether zinc and copper antagonize the effects of lead on the DCV.
为评估职业和环境因素对所有快速和慢速有髓大直径周围神经纤维的影响，我们测量了接触局部振动、铅、铊、苯乙烯、混合溶剂和酒精的男性以及糖尿病患者的神经传导速度（DCV）分布。结果表明，快速有髓大直径神经纤维的传导速度比慢速纤维对大多数有毒化学物质和物理因素更敏感。需要进一步研究来探讨DCV和传统周围神经传导速度中哪一个是这些因素亚临床效应更敏感的指标，以及锌和铜是否能拮抗铅对DCV的影响。
