Araki S, Yokoyama K, Murata K, Aono H
Br J Ind Med. 1986 May;43(5):321-6. doi: 10.1136/oem.43.5.321.
By measuring the distribution of conduction velocities (DCV) in sensory fibres of the median nerve, the effects of asymptomatic increased lead, zinc, and copper absorption on the conduction velocities of slower and faster nerve fibres were examined in 29 gun metal founders with blood lead (BPb) concentrations of 22-59 (mean 39) micrograms/dl (1.1-2.8 (mean 1.9) mumol/l). The results indicated that the conduction velocities of slower fibres were inversely affected by lead absorption, resulting in a significant reduction in the velocities at the BPb level of 40-59 micrograms/dl; on the other hand, the conduction velocities of faster fibres and the conventional sensory nerve conduction velocity were presumably positively affected by zinc absorption without a significant reduction in the velocities of faster fibres. It is suggested that assessment of the possible antagonistic effect of zinc is essential when conduction velocities are not decreased in lead exposed workers.
通过测量正中神经感觉纤维的传导速度分布（DCV），对29名血铅（BPb）浓度为22 - 59（平均39）微克/分升（1.1 - 2.8（平均1.9）微摩尔/升）的炮铜铸造工人，研究了无症状性铅、锌和铜吸收增加对较慢和较快神经纤维传导速度的影响。结果表明，较慢纤维的传导速度受铅吸收的反向影响，在BPb水平为40 - 59微克/分升时速度显著降低；另一方面，较快纤维的传导速度和传统感觉神经传导速度可能受锌吸收的正向影响，较快纤维的速度没有显著降低。建议当铅暴露工人的传导速度未降低时，评估锌的可能拮抗作用至关重要。
