de Graaff W E, de Jong B, Oosterhuis J W, van Echten-Arends J, Wiersema-Buist J, Schraffordt Koops H, Sleijfer D T
Department of Pathology, University of Groningen, The Netherlands.
Cancer Genet Cytogenet. 1991 Nov;57(1):59-68. doi: 10.1016/0165-4608(91)90190-6.
A case is described in which the mature and immature teratoma components of metastases of the same testicular nonseminomatous germ cell tumor were karyotyped. The highly similar karyotypes of both components suggest that the phenotypic difference is predominantly epigenetically determined.
本文描述了一例对同一睾丸非精原性生殖细胞肿瘤转移灶中的成熟和未成熟畸胎瘤成分进行核型分析的病例。两种成分高度相似的核型表明,表型差异主要由表观遗传决定。