Petit J M, Biggs J T
Pediatrics. 1977 Feb;59(2):283-7.
Tricyclic antidepressant plasma levels were measured in nine hospitalized adolescent oversdose patients to define the medical seriousness of the drug ingestion. Seven out of nine of these patients ingested medication prescribed for treatment of their psychiatric symptoms. Indications for tricyclic therapy in adolescents are vague. The more frequent use of these drugs makes the potential for life-threatening ingestions relatively common. The amount of drug ingested is usually poorly documented. Plasma measurements are of value in assessing the efficacy of the various medical treatments of overdose patients. Two of these nine overdoses were medically serious as defined by plasma measurements. Supportive care with cardiac monitoring was adequate in one case; however, a fatality occurred in the other under what could be described as optimal patient management conditions.
对9名住院的青少年过量服药患者测量了三环类抗抑郁药的血浆水平，以确定药物摄入的医学严重性。这9名患者中有7名服用了为治疗其精神症状而开的药物。青少年三环类疗法的适应症尚不明确。这些药物的频繁使用使得危及生命的摄入可能性相对常见。所摄入药物的量通常记录不佳。血浆测量对于评估过量服药患者各种医学治疗的疗效具有价值。根据血浆测量结果，这9例过量服药中有2例在医学上较为严重。其中1例通过心脏监测进行的支持性护理是足够的；然而，在可称为最佳患者管理条件下，另一例发生了死亡。
