Petit J M, Spiker D G, Biggs J T
J Nerv Ment Dis. 1976 Oct;163(4):289-93. doi: 10.1097/00005053-197610000-00009.
Thirty-six hospitalized patients who were considered by emergency room physicians to have ingested medically serious tricyclic overdoses were studied. The purpose of the project was to determine if psychiatric diagnosis and associated psychiatric factors correlated with the severity of the overdose as defined by plasma drug levels. Medically serious overdoses were ingested by patients with alcoholism, primary affective disorder, undiagnosed psychiatric illness, and Briquet's syndrome. Prior psychiatric treatment, prior admissions, prior overdoses, or precipitating events did not correlate with the medical severity of the ingestion. Attempting to predict the individual medical severity of the overdose from psychiatric factors resulted in a dangerous underestimation of the risk of patients with Briquet's syndrome and an overprediction in the case of primary affective disorder.
对36名被急诊医生认为摄入了具有严重医学后果的三环类药物过量的住院患者进行了研究。该项目的目的是确定精神科诊断及相关精神因素是否与血浆药物水平所定义的过量严重程度相关。酗酒、原发性情感障碍、未确诊的精神疾病和布里凯综合征患者摄入了具有严重医学后果的过量药物。既往精神科治疗、既往住院、既往过量用药或促发事件与摄入药物的医学严重程度无关。试图根据精神因素预测个体药物过量的医学严重程度，会导致对布里凯综合征患者的风险严重低估，而对原发性情感障碍患者则会高估。
