Gronier B, Azorin J M, Dassa D, Jeanningros R
Unité de Psychiatrie Biologique, C.N.R.S., Faculté de Médecine, Marseille, France.
Int Clin Psychopharmacol. 1993 Summer;8(2):87-93. doi: 10.1097/00004850-199300820-00002.
The kinetic characteristics of platelet L-tryptophan uptake were investigated in 23 untreated depressed patients and 18 healthy volunteers. A significant increase of 50% in the apparent Michaelis constant (Km) was observed in depressed patients compared with controls, without significant change in the maximal velocity (Vmax). After 1 month of successful antidepressant treatment the mean Km value decreased significantly and reached the control value. This result raises the possibility that the decrease in platelet tryptophan uptake affinity is a state-dependent marker for depression. It is likely that the transport alteration results in a decrease in platelet tryptophan accumulation. The effect of this peripheral membrane defect on brain serotonin function is discussed.
对23名未经治疗的抑郁症患者和18名健康志愿者的血小板L-色氨酸摄取动力学特征进行了研究。与对照组相比，抑郁症患者的表观米氏常数（Km）显著增加了50%，而最大速度（Vmax）没有显著变化。经过1个月成功的抗抑郁治疗后，平均Km值显著下降并达到对照组水平。这一结果增加了血小板色氨酸摄取亲和力降低是抑郁症状态依赖性标志物的可能性。转运改变很可能导致血小板色氨酸积累减少。本文讨论了这种外周膜缺陷对脑血清素功能的影响。
