Kim S Y, Nayak M S, Kita M, Marmor M F
Department of Ophthalmology, Stanford University School of Medicine, CA 94305-5308.
Invest Ophthalmol Vis Sci. 1994 Feb;35(2):664-8.
To determine the time course and reproducibility of electroretinogram recovery after short-term (5- to 20-minute) retinal ischemia in the light and in the dark.
Electroretinogram recovery was measured in Dutch rabbits after 5-, 10-, or 20-minute episodes of ocular ischemia, repeated three times at 1-hour intervals. Results were compared under light- and dark-adapted conditions.
The rate of b-wave recovery was highly reproducible after repetitive ischemic insults in the same eye. The rate of b-wave recovery varied in proportion to the duration of ischemia but generally reached 100% of preischemic levels within 45 to 60 minutes. Recovery was slower under dark-adapted conditions than under light-adapted conditions, and 10 minutes of ischemia appeared to be a critical duration to maximize light- and dark-adapted metabolic differences.
Because of the speed and reproducibility of electroretinogram recovery, the use of short-term ischemic episodes may facilitate studies on the pharmacologic therapy of retinal ischemia. It remains to be determined, however, whether the retinal effects of short-term ischemia are mediated by the same mechanisms as the effects of longer-term ischemia.
确定在明视觉和暗视觉条件下，短期（5至20分钟）视网膜缺血后视网膜电图恢复的时间进程和可重复性。
对荷兰兔进行5分钟、10分钟或20分钟的眼部缺血发作，每隔1小时重复3次，然后测量视网膜电图恢复情况。在明适应和暗适应条件下比较结果。
同一只眼睛重复缺血损伤后，b波恢复速率具有高度可重复性。b波恢复速率与缺血持续时间成比例变化，但一般在45至60分钟内达到缺血前水平的100%。暗适应条件下的恢复比明适应条件下慢，10分钟的缺血似乎是使明适应和暗适应代谢差异最大化的关键持续时间。
由于视网膜电图恢复的速度和可重复性，短期缺血发作的应用可能有助于视网膜缺血药物治疗的研究。然而，短期缺血的视网膜效应是否与长期缺血的效应由相同机制介导，仍有待确定。
