Nalbantgil I, Onder R, Kiliçcioğlu B, Türkoğlu C
Department of Cardiology, Ege University Hospital, Izmir, Turkey.
J Hum Hypertens. 1993 Jun;7(3):305-8.
Forty patients with mild to moderate hypertension were divided into two groups, 20 patients (group A) received 240 mg verapamil and 20 patients (group B) received 20 mg nitrendipine daily during the first six weeks. During the second six weeks, all 40 patients were given 10 mg nitrendipine plus 120 mg verapamil. After the combination therapy, group B received verapamil, 240 mg and group A nitrendipine 20 mg for a further period of six weeks. When verapamil and nitrendipine were used alone, BP decreased significantly in each group. However, BP decreased more when the combination therapy was used and increased when the treatment was changed to single drug therapy from the two-drug combination. In addition, side-effects were three to four times fewer during the combination therapy. It is concluded that the combination of two different calcium antagonists in the treatment of hypertension provides a new dimension to therapy.
40例轻至中度高血压患者被分为两组，在最初六周，20例患者（A组）每日服用240毫克维拉帕米，20例患者（B组）每日服用20毫克尼群地平。在接下来的六周，所有40例患者均服用10毫克尼群地平加120毫克维拉帕米。联合治疗后，B组继续服用240毫克维拉帕米，A组继续服用20毫克尼群地平，持续六周。当单独使用维拉帕米和尼群地平时，每组血压均显著下降。然而，联合治疗时血压下降更多，从两药联合改为单药治疗时血压升高。此外，联合治疗期间副作用减少了三至四倍。结论是，两种不同的钙拮抗剂联合治疗高血压为治疗提供了新的维度。
