Ananth L, Prete P E, Kashyap M L
Section of Rheumatology, University of California, Irvine.
Metabolism. 1993 Jul;42(7):803-6. doi: 10.1016/0026-0495(93)90050-x.
Synovial fluid (SF) of patients with rheumatoid arthritis (RA) has been noted to contain cholesterol crystals and increased amounts of cholesterol compared with normal SF. SF, plasma apolipoproteins (apos) A-I and B, and cholesterol in 12 untreated classic RA patients (inflammatory arthritis) and eight untreated degenerative joint disease ([DJD] noninflammatory arthritis) patients were analyzed. Results showed that mean apo A-I, apo B, and cholesterol levels of RA SF were significantly higher than those of DJD SF (apo A-I, P = .004; apo B, P = .0008; cholesterol, P = .0004). Regression analyses of plasma and SF apo A-I and apo B (r = .72, P = .008 and r = .63, P = .02, respectively) suggested an increased permeability for these lipoprotein constituents across RA synovial membrane that was not observed in DJD synovial membrane. These data suggest that RA synovium but not DJD synovium is more permeable to major apoproteins of low- and high-density lipoproteins (LDL and HDL). These apolipoproteins have been shown to influence the immune response and may therefore be involved in the pathogenesis of RA.
与正常滑液相比，类风湿关节炎（RA）患者的滑液（SF）中已发现含有胆固醇晶体且胆固醇含量增加。对12例未经治疗的典型RA患者（炎性关节炎）和8例未经治疗的退行性关节病（DJD，非炎性关节炎）患者的滑液、血浆载脂蛋白（apo）A-I和B以及胆固醇进行了分析。结果显示，RA滑液的平均apo A-I、apo B和胆固醇水平显著高于DJD滑液（apo A-I，P = .004；apo B，P = .0008；胆固醇，P = .0004）。血浆和滑液中apo A-I和apo B的回归分析（r分别为.72，P = .008和r = .63，P = .02）表明，这些脂蛋白成分在RA滑膜中的通透性增加，而在DJD滑膜中未观察到这种情况。这些数据表明，RA滑膜而非DJD滑膜对低密度和高密度脂蛋白（LDL和HDL）的主要载脂蛋白具有更高的通透性。这些载脂蛋白已被证明会影响免疫反应，因此可能参与RA的发病机制。
