Park Y B, Lee S K, Lee W K, Suh C H, Lee C W, Lee C H, Song C H, Lee J
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
J Rheumatol. 1999 Aug;26(8):1701-4.
To investigate lipid profiles in patients with untreated active rheumatoid arthritis (RA) and to assess the relationship of the inflammatory condition of RA with lipid profiles.
Forty-two patients with RA and 42 age and sex matched healthy controls were studied. Patients with RA had not been treated with corticosteroid or disease modifying antirheumatic drugs prior to the study. Total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein A1 (apo A1), apolipoprotein B (apo B), lipoprotein(a) [Lp(a)], and C-reactive protein (CRP) were measured in both groups.
The levels of apo A1 and HDL-cholesterol were significantly lower in patients than in controls (128.5 vs. 151.8 mg/dl, 41.2 vs. 54.9 mg/dl, respectively). The level of Lp(a) was significantly higher in patients than in controls (27.1 vs. 18.0 mg/dl). The ratios of apo B/apo A1, total cholesterol/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol were significantly higher in patients than in controls (0.82 vs. 0.67, 4.4 vs. 3.4, 2.8 vs. 1.9, respectively). CRP showed a significant correlation with apo A1 (r = -0.44, p<0.01) and HDL-cholesterol (r = -0.35, p<0.05).
Our study suggests that patients with untreated active RA have altered lipoprotein and apolipoprotein patterns that may possibly expose them to higher risk of atherosclerosis. The inflammatory condition of RA may affect the metabolism of HDL-cholesterol and apo A1.
研究未经治疗的活动性类风湿关节炎（RA）患者的血脂谱，并评估RA的炎症状态与血脂谱之间的关系。
对42例RA患者和42例年龄、性别匹配的健康对照者进行研究。RA患者在研究前未接受过皮质类固醇或改善病情抗风湿药物治疗。测量两组患者的总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-胆固醇）、低密度脂蛋白胆固醇（LDL-胆固醇）、载脂蛋白A1（apo A1）、载脂蛋白B（apo B）、脂蛋白(a) [Lp(a)]和C反应蛋白（CRP）。
患者的apo A1和HDL-胆固醇水平显著低于对照组（分别为128.5 vs. 151.8 mg/dl，41.2 vs. 54.9 mg/dl）。患者的Lp(a)水平显著高于对照组（27.1 vs. 18.0 mg/dl）。患者的apo B/apo A1、总胆固醇/HDL-胆固醇和LDL-胆固醇/HDL-胆固醇比值显著高于对照组（分别为0.82 vs. 0.67，4.4 vs. 3.4，2.8 vs. 1.9）。CRP与apo A1（r = -0.44，p<0.01）和HDL-胆固醇（r = -0.35，p<0.05）呈显著相关。
我们的研究表明，未经治疗的活动性RA患者的脂蛋白和载脂蛋白模式发生改变，这可能使他们面临更高的动脉粥样硬化风险。RA的炎症状态可能影响HDL-胆固醇和apo A1的代谢。
