Kersten M J, Mertens M J, Pals S T, Reiss P, van Oers M H
Afd. Interne Geneeskunde, Academisch Medisch Centrum, Amsterdam.
Ned Tijdschr Geneeskd. 1993 Jul 10;137(28):1396-400.
Non-Hodgkin lymphoma is seen in approximately 5% of patients with AIDS. In recent years, the incidence has increased due to an extension of the average lifespan of HIV-infected individuals. In this article we describe the histological and clinical features of 45 patients with HIV-related non-Hodgkin lymphoma seen at the Academic Medical Centre between 1984 and 1991. There were 43 men and 2 women with a median age of 40 years. Most patients had high-grade B-cell lymphoma; 85% had extranodal sites. Prognosis was poor: overall median survival was only 3.8 months. Twelve patients were treated with 3 or more courses of chemotherapy: their median survival was 8 months. In 7 of 12 patients a complete remission was obtained; their median survival was 18 months. A history of AIDS was a poor prognostic factor.
非霍奇金淋巴瘤见于约5%的艾滋病患者。近年来，由于感染HIV个体的平均寿命延长，其发病率有所上升。在本文中，我们描述了1984年至1991年间在学术医学中心就诊的45例HIV相关非霍奇金淋巴瘤患者的组织学和临床特征。患者中有43名男性和2名女性，中位年龄为40岁。大多数患者患有高级别B细胞淋巴瘤；85%有结外部位。预后较差：总体中位生存期仅为3.8个月。12例患者接受了3个或更多疗程的化疗：他们的中位生存期为8个月。12例患者中有7例获得完全缓解；他们的中位生存期为18个月。艾滋病病史是一个不良预后因素。
