基因图谱整合：21号染色体

Integration of gene maps: chromosome 21.

作者信息

Lawrence S, Collins A, Keats B J, Hulten M, Morton N E

机构信息

University of Southampton, Princess Anne Hospital, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7210-4. doi: 10.1073/pnas.90.15.7210.

DOI:10.1073/pnas.90.15.7210

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC47106/

Abstract

Physical, cytogenetic, and genetic data including microsatellite markers and a covering sequence-tagged site (STS) map have been entered into a location database and integrated into a summary map that subsumes a composite physical location, sex-specific genetic locations, cytogenetic and regional assignments, mouse homology, rank, and references. With the omission of 52 loci whose location is known only from cytogenetic assignment to an interval greater than 10 megabases, there are 198 loci in the covering STS map and an additional 145 loci. The physical length is consistent with 11 megabases for 21p and 39 megabases for 21q. With error filtration and allowance for high interference, the genetic length in males corresponds to the chiasma map (54.7 centimorgans), and the genetic length in females is 76.5 centimorgans. The relation between map integration and the STS paradigm is illustrated and discussed.

摘要

包括微卫星标记和覆盖序列标签位点（STS）图谱在内的物理、细胞遗传学和遗传学数据已被录入一个定位数据库，并整合到一个汇总图谱中，该图谱包含复合物理位置、性别特异性遗传位置、细胞遗传学和区域定位、小鼠同源性、排序以及参考文献。除去52个仅通过细胞遗传学定位到大于10兆碱基区间而得知其位置的基因座，覆盖性STS图谱中有198个基因座，另有145个基因座。21号染色体短臂（21p）的物理长度与11兆碱基一致，21号染色体长臂（21q）的物理长度与39兆碱基一致。经过误差过滤并考虑到高干扰因素后，雄性的遗传长度对应于交叉图谱（54.7厘摩），雌性的遗传长度为76.5厘摩。文中阐述并讨论了图谱整合与STS范式之间的关系。

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