MAP，一种用于多重成对连锁分析的专家系统。

MAP, an expert system for multiple pairwise linkage analysis.

作者信息

Morton N E, Andrews V

机构信息

Department of Community Medicine, University of Southampton.

出版信息

Ann Hum Genet. 1989 Jul;53(3):263-9. doi: 10.1111/j.1469-1809.1989.tb01793.x.

DOI:10.1111/j.1469-1809.1989.tb01793.x

PMID:2596832

Abstract

The logic of a program for multiple pairwise linkage analysis under interference is set forth, including a seriation algorithm to obtain a trial order, a mapping bootstrap to improve the trial order, and three procedures for quality control to detect mistyping. This approach is compared with multipoint analysis under null interference, which substantially overestimates map length and cannot incorporate a variety of data.

摘要

阐述了一种用于在干扰情况下进行多重成对连锁分析的程序逻辑，包括用于获得试验顺序的序列化算法、用于改进试验顺序的映射自展法，以及用于检测错误分型的三个质量控制程序。将这种方法与无干扰情况下的多点分析进行了比较，后者会大幅高估图谱长度且无法纳入多种数据。