Kohlert J G, Bloch G J
Department of Psychology, Brigham Young University, Provo, UT 84602.
Physiol Behav. 1993 Jun;53(6):1215-8. doi: 10.1016/0031-9384(93)90382-p.
A number of animal models for attention deficient-hyperactivity disorder (ADHD), a common childhood disorder, have been developed. However, none of these models are truly representative of naturally occurring developmental ADHD. In such models, hyperactivity is induced by electrical or chemical brain lesions, by pharmacological manipulation, or by genetic breeding that is coupled with hypertension. Based on the observation that some hyposexual rats also are hyperactive, we have studied these rats in order to determine whether they portray characteristics representative of ADHD. Results of open field testing, response to stimulant medication challenge, and measurement of the rat's ability to block irrelevant information in a conditioned avoidance response demonstrate three properties characteristic of ADHD: a) a high level of spontaneous motor activity; b) an attenuation of motor activity in response to amphetamine; and c) a deficit in selective attention. These data indicate that these rats may be a model for the study of ADHD.
已经开发出了多种针对注意力缺陷多动障碍（ADHD，一种常见的儿童疾病）的动物模型。然而，这些模型中没有一个能真正代表自然发生的发育性ADHD。在这类模型中，多动是由脑电或化学损伤、药物操纵或与高血压相关的基因育种诱导产生的。基于一些性欲减退的大鼠也多动这一观察结果，我们对这些大鼠进行了研究，以确定它们是否呈现出ADHD的典型特征。旷场试验结果、对兴奋剂药物激发的反应以及对大鼠在条件性回避反应中阻断无关信息能力的测量，都证明了ADHD的三个典型特征：a）高水平的自发运动活动；b）对苯丙胺反应时运动活动减弱；c）选择性注意力缺陷。这些数据表明，这些大鼠可能是用于研究ADHD的一种模型。
