Butera P C, Bradway D M, Cataldo N J
Department of Psychology, Niagara University, NY 14109.
Physiol Behav. 1993 Jun;53(6):1235-8. doi: 10.1016/0031-9384(93)90387-u.
Data obtained from a wide variety of mammalian species indicate that feeding behavior can be influenced by changes in endogenous estrogens and by exogenous estrogenic treatments. The present experiment represents an initial investigation of the hypothesis that the suppression of food intake by estradiol is mediated by an enhancement of the satiety effect of cholecystokinin (CCK). Twenty-four female rats were ovariectomized and implanted either with a 5% estradiol silastic capsule or an empty capsule on the day of surgery. Three weeks later, animals received IP injections of CCK-octapeptide (5.0 or 10.0 micrograms/kg) or saline after 24-h food deprivation. Food and water intake were measured 60 min after treatment. Although CCK suppressed feeding in all subjects, the effects on food intake were greater in estradiol-treated females. CCK injections also reduced water intake, but there was no interaction between estradiol and CCK on drinking. These findings indicate that the inhibitory effect of CCK on food intake is enhanced in females treated with a physiological dose of estradiol, and suggest that the effects of estradiol on feeding behavior may be mediated by a potentiation of the satiety effect of CCK.
从多种哺乳动物物种获得的数据表明，摄食行为会受到内源性雌激素变化和外源性雌激素处理的影响。本实验是对以下假设的初步研究：雌二醇对食物摄入的抑制作用是通过增强胆囊收缩素（CCK）的饱腹感效应来介导的。24只雌性大鼠在手术当天进行卵巢切除，并植入一个含5%雌二醇的硅橡胶胶囊或一个空胶囊。三周后，动物在禁食24小时后接受腹腔注射CCK八肽（5.0或10.0微克/千克）或生理盐水。治疗后60分钟测量食物和水的摄入量。虽然CCK抑制了所有受试动物的摄食，但对食物摄入的影响在接受雌二醇处理的雌性动物中更大。注射CCK也减少了水的摄入量，但雌二醇和CCK对饮水没有相互作用。这些发现表明，在接受生理剂量雌二醇处理的雌性动物中，CCK对食物摄入的抑制作用增强，这表明雌二醇对摄食行为的影响可能是通过增强CCK的饱腹感效应来介导的。
