Mahon R J, Wardhaugh K G, van Gerwen A C, Whitby W A
CSIRO, Division of Entomology, Canberra, A.C.T., Australia.
Vet Parasitol. 1993 Jun;48(1-4):193-204. doi: 10.1016/0304-4017(93)90155-g.
When fed dung from sheep treated with ivermectin 24 h previously, Lucilia cuprina adults exhibited reduced survival, delayed ovarian development and reduced egg production. These effects were absent in dung produced 2 or more days after ivermectin treatment. Such transient toxicity is ideal to restrict the evolution of resistance to this drug. This situation may change if the current practice of oral treatment is replaced by a slow-release system of administering avermectins. The avoidance of coincidental evolution of resistance is critical to the long-term welfare of the Australian sheep industry as the avermectins represent an important, and as yet unexploited, insecticide for the treatment of flystrike caused by Lucilia cuprina.
当给绿蝇 Lucilia cuprina 的成虫投喂 24 小时前用伊维菌素处理过的绵羊粪便时，它们的存活率降低，卵巢发育延迟，产卵量减少。在伊维菌素处理 2 天或更长时间后产生的粪便中则没有这些影响。这种短暂的毒性对于限制对该药物的抗性进化非常理想。如果目前的口服治疗方法被阿维菌素的缓释给药系统所取代，这种情况可能会改变。由于阿维菌素是治疗由绿蝇 Lucilia cuprina 引起的羊蝇蛆病的一种重要且尚未充分利用的杀虫剂，避免抗性的同时进化对于澳大利亚养羊业的长期福祉至关重要。
