Rizzo M C, Arruda L K, Chapman M D, Fernandez-Caldas E, Baggio D, Platts-Mills T A, Naspitz C K
Paulista School of Medicine, São Paulo, Brazil.
Ann Allergy. 1993 Aug;71(2):152-8.
We compared exposure and levels of IgE and IgG antibodies to inhalant allergens in 20 children with asthma and positive skin tests to Dermatophagoides pteronyssinus, living in São Paulo, to 20 control children without history of asthma or allergy and negative skin tests to D. pteronyssinus, D. farinae, and Blomia tropicalis. In 16/20 and 17/20 houses of asthmatic and control children, respectively, at least one sample was obtained which contained > 10 micrograms Der p I/g of dust. Serum IgE antibodies to D. pteronyssinus and Blomia tropicalis were > 200 RAST U/mL in 19/20 and in 16/20 asthmatic children, respectively. In the control group, IgE antibodies to either mite species were < 40 RAST U/mL in most cases. IgG anti-Der p I and anti-Der f I antibodies were detected in 17/20 asthmatics, as opposed to 3/20 controls. Neither cat nor cockroach allergens caused significant sensitization among asthmatic or control children. Although exposure to high levels of mite allergens was common in São Paulo, significant IgE and IgG antibody responses were detected only in children with asthma.
我们比较了20名患有哮喘且对尘螨皮肤试验呈阳性的儿童与20名无哮喘或过敏史且对屋尘螨、粉尘螨和热带无爪螨皮肤试验呈阴性的对照儿童，对吸入性过敏原的暴露情况以及IgE和IgG抗体水平。在哮喘儿童和对照儿童的住所中，分别有16/20和17/20的住所至少采集到一份每克灰尘中含>10微克Der p I的样本。哮喘儿童中，分别有19/20和16/20对屋尘螨和热带无爪螨的血清IgE抗体>200 RAST U/mL。在对照组中，大多数情况下，对这两种螨类的IgE抗体<40 RAST U/mL。17/20的哮喘儿童检测到IgG抗Der p I和抗Der f I抗体，而对照儿童中这一比例为3/20。猫和蟑螂过敏原在哮喘儿童或对照儿童中均未引起显著致敏。尽管在圣保罗，暴露于高水平的螨过敏原很常见，但仅在哮喘儿童中检测到显著的IgE和IgG抗体反应。
