Grigg J, Barber A, Silverman M
Royal Postgraduate Medical School, Hammersmith Hospital, London.
Arch Dis Child. 1993 Jul;69(1 Spec No):49-51. doi: 10.1136/adc.69.1_spec_no.49.
Lower concentrations of uncorrected glutathione in the bronchoalveolar lavage fluid were found on the first day of life in seven infants who subsequently developed chronic lung disease when compared with 27 infants who did not require supplemental oxygen at 36 weeks' postconceptional age. The concentration of glutathione on the first day was independent of gestational age. These preliminary results suggest that glutathione accumulates in the lung epithelial lining fluid of preterm infants and that a relative deficiency may predispose to lung injury.
与27名在孕龄36周时无需补充氧气的婴儿相比，7名随后患上慢性肺病的婴儿在出生第一天的支气管肺泡灌洗液中未校正谷胱甘肽浓度较低。出生第一天谷胱甘肽的浓度与胎龄无关。这些初步结果表明，谷胱甘肽在早产儿肺上皮衬液中蓄积，相对缺乏可能易导致肺损伤。
