Beutler E, Gelbart T
J Lab Clin Med. 1985 May;105(5):581-4.
The total glutathione concentration (oxidized plus reduced) of human plasma was investigated. Glutathione was found to disappear when added to plasma, the loss of reduced glutathione being much more rapid than the loss of oxidized glutathione. The glutathione content of plasma from normal humans was found to be 0.91 +/- 0.24 mumol/L (mean +/- 1 SD) when plasma extracts were prepared exactly 10 minutes after the blood had been drawn. The glutathione content of rat plasma was about 15 times as high as that of human plasma. Patients with a variety of malignant disorders were found to have markedly lowered plasma glutathione levels. This did not seem to be associated with chemotherapy or with type of neoplasm. The administration of acetaminophen to rabbits and to human volunteers did not affect plasma glutathione levels.
对人血浆中总谷胱甘肽浓度（氧化型加还原型）进行了研究。发现谷胱甘肽添加到血浆中时会消失，还原型谷胱甘肽的损失比氧化型谷胱甘肽的损失快得多。当在采血后恰好10分钟制备血浆提取物时，正常人血浆中的谷胱甘肽含量为0.91±0.24μmol/L（平均值±1个标准差）。大鼠血浆中的谷胱甘肽含量约为人血浆的15倍。发现患有各种恶性疾病的患者血浆谷胱甘肽水平明显降低。这似乎与化疗或肿瘤类型无关。给兔子和人类志愿者服用对乙酰氨基酚不影响血浆谷胱甘肽水平。
