Neinstein L S, Atkinson J, Diament M
Division of Adolescent Medicine, Children's Hospital of Los Angeles, CA 90054-0700.
J Adolesc Health. 1993 Jun;14(4):277-81. doi: 10.1016/1054-139x(93)90174-n.
This study examined the prevalence and outcome of breast masses in adolescent females and compared these teens to those without breast masses. A longitudinal study of adolescents with breast masses was conducted from October 1984 through January 1990. The prevalence of discrete breast masses in the 13-month study period was 13/400 (3.25%) among new female patients. The mean length and width of the masses were 2.8 and 1.9 cm; 86% had a solitary mass. Of 61 diagnosed with breast masses, 39 were followed for up to 40 months (mean, 7 months). Teens with a mass were older (16.8 versus 15.1 years, p < 0.001) and had a greater chance of a family history of breast disease (26% versus 10.5%, p < 0.05) than those without a breast mass. Of 39 teens returning for at least one follow-up visit, 10 had a clinical diagnosis of "fibrocystic changes." Of these, the lesions resolved in six. Of the 29 teens with a discrete mass on examination, 7 underwent surgery and were found to have fibroadenomas. Nine of the 29 teens had masses which resolved over 1-12 months, six teens had masses which remained unchanged over 3-40 months, while four had masses which became smaller, and two had masses which became larger. One teen with mastitis improved. Eighteen underwent ultrasonographic examination at the breast. Of the 12 teens found to have a solid mass on ultrasound, none had a mass that resolved on follow-up examination.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究调查了青春期女性乳腺肿块的患病率及转归情况,并将这些青少年与无乳腺肿块的青少年进行比较。1984年10月至1990年1月,对患有乳腺肿块的青少年进行了一项纵向研究。在13个月的研究期内,新女性患者中离散性乳腺肿块的患病率为13/400(3.25%)。肿块的平均长度和宽度分别为2.8厘米和1.9厘米;86%为单发肿块。在61例被诊断为乳腺肿块的患者中,39例接受了长达40个月(平均7个月)的随访。有肿块的青少年比无乳腺肿块的青少年年龄更大(16.8岁对15.1岁,p<0.001)且有乳腺疾病家族史的几率更高(26%对10.5%,p<0.05)。在39例至少返回进行一次随访的青少年中,10例临床诊断为“纤维囊性改变”。其中,6例病变消退。在29例检查发现有离散性肿块的青少年中,有7例接受了手术,结果发现患有纤维腺瘤。29例青少年中有9例肿块在1 - 12个月内消退,6例青少年的肿块在3 - 40个月内保持不变,4例肿块变小,2例肿块变大。1例乳腺炎患者病情好转。18例接受了乳房超声检查。在超声检查发现有实性肿块的12例青少年中,随访检查时肿块均未消退。(摘要截短至250字)