Perrière G, Gautier C
Laboratoire de Biométrie, Génétique et Biologie des Populations, URA CNRS no 243 Université Claude Bernard, Lyon I, Villeurbanne, France.
Biochimie. 1993;75(5):415-22.
ColiGene is an object-centered knowledge base for the study of gene expressivity in Escherichia coli by DNA sequence analysis. This system was developed with the knowledge base management system SHIRKA. Objects represented in ColiGene are biological structures such as genes or regulatory signals. They are organized in a hierarchical structure of classes, subclasses and instances. Navigation through the knowledge base and the building of queries are made using a graphical interface. The base is coupled with the data base ACNUC which structures a specialized collection of sequences: EcoSeq. Several tools are also associated to ColiGene, either for sequence analysis or for a more general purpose. Some biological results have been obtained using ColiGene which are summarized here.
ColiGene是一个以对象为中心的知识库，用于通过DNA序列分析研究大肠杆菌中的基因表达。该系统是使用知识库管理系统SHIRKA开发的。ColiGene中表示的对象是诸如基因或调控信号之类的生物结构。它们以类、子类和实例的层次结构进行组织。通过图形界面进行知识库的导航和查询构建。该知识库与数据库ACNUC耦合，ACNUC构建了一个专门的序列集合：EcoSeq。还有一些工具也与ColiGene相关联，用于序列分析或更通用的目的。使用ColiGene已经获得了一些生物学结果，在此进行总结。
