Zheng W, Linet M S, Shu X O, Pan R P, Gao Y T, Fraumeni J F
Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD.
Cancer Causes Control. 1993 Jul;4(4):361-8. doi: 10.1007/BF00051339.
A population-based case-control interview study of 486 adult leukemia cases and 502 healthy controls was carried out in Shanghai, People's Republic of China during 1987-89 to evaluate the etiologic role of prior medical conditions, medications, and diagnostic X-rays. Risks were examined separately for 236 cases with acute non-lymphocytic leukemia (ANLL), 79 with chronic myeloid leukemia (CML), 81 with acute lymphocytic leukemia (ALL), and 21 with chronic lymphocytic leukemia (CLL). Little difference was found between cases and controls for prior history of diabetes, hypertension, allergic conditions, most medications, and diagnostic X-rays. A few significant associations were observed for appendectomy, tuberculosis, and for several other chronic disorders with specific leukemia cell types, but the odds ratio estimates for most of these ranged from two to three and, with the exception of the two specified above, were based generally on five or fewer exposed controls. In contrast to an association with childhood leukemia in Shanghai, prior use of chloramphenicol was not linked with ANLL or other forms of adult leukemia. Further research is needed to clarify the relation of specific medical conditions and exposures with particular subtypes of leukemia, and to examine reasons for the low incidence of CLL in China and other Asian populations.
1987 - 1989年期间，在中国上海对486例成年白血病患者和502名健康对照者进行了一项基于人群的病例对照访谈研究，以评估既往疾病、药物使用和诊断性X线检查的病因学作用。分别对236例急性非淋巴细胞白血病（ANLL）、79例慢性粒细胞白血病（CML）、81例急性淋巴细胞白血病（ALL）和21例慢性淋巴细胞白血病（CLL）患者的风险进行了检查。病例组和对照组在糖尿病、高血压、过敏状况、大多数药物使用和诊断性X线检查的既往史方面差异不大。观察到阑尾切除术、结核病以及其他一些慢性疾病与特定白血病细胞类型之间存在一些显著关联，但其中大多数的比值比估计值在2至3之间，除上述两种情况外，一般基于5名或更少的暴露对照。与上海儿童白血病的关联情况不同，既往使用氯霉素与ANLL或其他形式的成人白血病无关。需要进一步研究以阐明特定疾病状况和暴露与白血病特定亚型之间的关系，并探讨中国和其他亚洲人群中CLL发病率低的原因。
