Crow T, Forrester J
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.
Brain Res. 1993 Jun 4;613(1):61-6. doi: 10.1016/0006-8993(93)90454-u.
One-trial conditioning of Hermissenda produces short- and long-term enhancement of generator potentials in identified type B-photoreceptors. The induction of short-term enhancement is blocked by kinase inhibitors and down-regulation of protein kinase C. We now report that established short- and long-term enhancement produced by one-trial conditioning is not reversed by the kinase inhibitors H-7 or sphingosine. These results indicate that persistent protein kinase C activity is not required in the maintenance or expression of enhancement.
对海兔进行一次性条件反射可使已识别的B型光感受器的发生器电位产生短期和长期增强。激酶抑制剂和蛋白激酶C的下调可阻断短期增强的诱导。我们现在报告，由一次性条件反射产生的已确立的短期和长期增强不会被激酶抑制剂H-7或鞘氨醇逆转。这些结果表明，持续性蛋白激酶C活性在增强的维持或表达中并非必需。
