Baily R G, Lehman J C, Gubin S S, Musch T I
Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033.
Cardiovasc Res. 1993 May;27(5):851-5. doi: 10.1093/cvr/27.5.851.
The aim was to evaluate whether two dimensional echocardiographic/Doppler (echo/Doppler) techniques could be used to detect left ventricular damage rapidly, accurately, and non-invasively in rats with a myocardial infarction.
Female Wistar rats were initially subjected to either a sham operation or surgery to induce a myocardial infarct by ligating the left main coronary artery. Following a minimum of six weeks to recover from the surgery, all rats were re-anaesthetised and cardiac and stroke indexes were determined at similar heart rates, using echo/Doppler techniques. Postmortem histological assessment of myocardial infarct size was compared with the non-invasive detection of left ventricular wall motion abnormalities, left ventricular dilatation, and the presence of a left ventricular aneurysm found in the living animal.
Rats with myocardial infarction (n = 8) showed a 33(SEM 4)% reduction (p < 0.01) in cardiac index (due to a 33% reduction in stroke index) when compared to their non-infarcted counterparts (n = 5). In addition, a significant correlation (r = 0.84; n = 25; p < 0.01) was found between the assessment of left ventricular damage via non-invasive echo/Doppler measurements and the histological determination of infarct size.
These results support the conclusion that two dimensional echo/Doppler techniques can be used to estimate rapidly and non-invasively the degree of left ventricular damage produced in living rats with myocardial infarction when compared to non-infarcted controls.
评估二维超声心动图/多普勒（超声/多普勒）技术能否快速、准确且无创地检测心肌梗死大鼠的左心室损伤。
雌性Wistar大鼠最初接受假手术或通过结扎左冠状动脉主干诱导心肌梗死的手术。术后至少六周恢复后，所有大鼠再次麻醉，使用超声/多普勒技术在相似心率下测定心脏和卒中指数。将心肌梗死大小的死后组织学评估与活体动物中左心室壁运动异常、左心室扩张和左心室瘤的无创检测结果进行比较。
与未梗死的大鼠（n = 5）相比，心肌梗死大鼠（n = 8）的心脏指数降低了33（标准误4）%（p < 0.01）（由于卒中指数降低了33%）。此外，通过无创超声/多普勒测量评估左心室损伤与梗死大小的组织学测定之间存在显著相关性（r = 0.84；n = 25；p < 0.01）。
这些结果支持以下结论：与未梗死对照相比，二维超声/多普勒技术可用于快速、无创地估计心肌梗死活体大鼠左心室损伤的程度。
