Miranda Amarildo, Costa-e-Sousa Ricardo H, Werneck-de-Castro João P S, Mattos Elisabete C, Olivares Emerson L, Ribeiro Vanessa P, Silva Márcia G, Goldenberg Regina C S, Campos-de-Carvalho Antônio C
Laboratório de Eletrofisiologia Cardíaca, CCS-UFRJ, Rio de Janeiro, RJ, Brazil.
An Acad Bras Cienc. 2007 Dec;79(4):639-48. doi: 10.1590/s0001-37652007000400006.
In animal models the evaluation of myocardial infarct size in vivo and its relation to the actual lesion found post mortem is still a challenge. The purpose of the current study was to address if the conventional electrocardiogram (ECG) and/or echocardiogram (ECHO) could be used to adequately predict the size of the infarct in rats. Wistar rats were infarcted by left coronary ligation and then ECG, ECHO and histopathology were performed at 1, 7 and 28 days after surgery. Correlation between infarct size by histology and Q wave amplitude in lead L1 was only found when ECGs were performed one day post-surgery. Left ventricular diastolic and systolic dimensions correlated with infarct size by ECHO on day 7 post-infarction. On days 7 and 28 post-infarction, ejection indexes estimated by M-mode also correlated with infarct size. In summary we show that conventional ECG and ECHO methods can be used to estimate infarct size in rats. Our data suggest that the 7-day interval is actually the most accurate for estimation of infarct size by ECHO.
在动物模型中，体内评估心肌梗死面积及其与死后发现的实际病变的关系仍然是一项挑战。本研究的目的是探讨传统心电图（ECG）和/或超声心动图（ECHO）是否可用于充分预测大鼠梗死面积。通过左冠状动脉结扎使Wistar大鼠发生梗死，然后在术后1、7和28天进行心电图、超声心动图和组织病理学检查。仅在术后一天进行心电图检查时，才发现组织学梗死面积与L1导联Q波振幅之间存在相关性。梗死7天后，左心室舒张和收缩直径与超声心动图测得的梗死面积相关。在梗死7天和28天时，M型估算的射血指数也与梗死面积相关。总之，我们表明传统心电图和超声心动图方法可用于估计大鼠梗死面积。我们的数据表明，7天的时间间隔实际上是通过超声心动图估计梗死面积最准确的时间。
