Zarco C, Lahuerta-Palacios J J, Borrego L, Toscano R, Gil R, Iglesias L
Department of Dermatology, 12 de Octubre Hospital Medical School, Madrid, Spain.
Clin Exp Dermatol. 1993 May;18(3):263-7. doi: 10.1111/j.1365-2230.1993.tb02184.x.
The development of a large-cell non-Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45-year-old man with B-cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large-cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.
患有慢性淋巴细胞白血病的患者发生大细胞非霍奇金淋巴瘤被称为里氏综合征，是白血病可能发生的间变转化之一。皮肤受累极为罕见。本文报告了一名45岁患有B细胞慢性淋巴细胞白血病男性的病例。五年后其四肢出现多个皮肤结节。皮肤活检显示为弥漫性大细胞淋巴瘤，其细胞表面免疫球蛋白轻链同种型与白血病相同，提示这两种肿瘤之间存在原发关系。
