HIV感染患者血清中IL-8水平升高。
Elevated serum levels of IL-8 in patients with HIV infection.
作者信息
Matsumoto T, Miike T, Nelson R P, Trudeau W L, Lockey R F, Yodoi J
机构信息
Department of Child Development, Kumamoto University Medical School, Japan.
出版信息
Clin Exp Immunol. 1993 Aug;93(2):149-51. doi: 10.1111/j.1365-2249.1993.tb07957.x.
Abstract
Serum levels of IL-8 were determined in HIV-infected individuals and the results were compared with those for HIV- controls. The IL-8 levels were measured by an ELISA with a MoAb and a polyclonal antibody to recombinant IL-8. The means and 95% confidence intervals of IL-8 in sera of 36 HIV-infected individuals and 32 matched controls were 275 and 216-349 pg/ml, and 8 and 4-14 pg/ml, respectively, showing a 34-fold increase in IL-8 in the circulation of HIV-infected individuals. This increase does not appear to be related to the disease state, infection or systemic medical agents. This finding suggests the possible involvement of IL-8 in the pathogenesis of HIV-induced disease.
摘要
测定了HIV感染者的血清白细胞介素-8（IL-8）水平，并将结果与HIV阴性对照者进行比较。IL-8水平通过使用针对重组IL-8的单克隆抗体和多克隆抗体的酶联免疫吸附测定（ELISA）来测量。36名HIV感染者和32名匹配对照者血清中IL-8的平均值及95%置信区间分别为275及216 - 349 pg/ml，以及8及4 - 14 pg/ml，表明HIV感染者循环中的IL-8升高了34倍。这种升高似乎与疾病状态、感染或全身性药物无关。这一发现提示IL-8可能参与了HIV诱发疾病的发病机制。
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