Rodriguez-Merchan E C
La Paz University Hospital, Madrid, Spain.
Haemophilia. 2006 Jul;12(4):337-44. doi: 10.1111/j.1365-2516.2006.01285.x.
Radiation synoviorthesis is a very effective procedure that decreases both the frequency and the intensity of recurrent ankle bleeds related to ankle synovitis. The procedure should be performed as soon as possible to minimize the degree of articular cartilage damage. It can also be used in patients with inhibitors with minimal risk of complications. On average, the efficacy of the procedure ranges from 76% to 80%, and can be performed at any age. The procedure slows the cartilaginous damage which intra-articular blood tends to produce in the long term. After 30 years of using radiation synovectomy worldwide, no damage has been reported in relation to the radioactive materials. Radiation synovectomy is currently the preferred procedure when radioactive materials are available; however, chemical synoviorthesis is an effective alternative method if radioactive materials are not available. Personal experience and the general recommendation among orthopaedic surgeons and haematologists is that when three early consecutive synoviorthesis (repeated every 3 months) fail to halt synovitis, a surgical synovectomy (open or by arthroscopy) should be immediately considered. For advanced haemophilic arthropathy of the ankle, the best solution is an ankle arthrodesis. Primary prophylaxis and radioactive synoviorthesis are the best ways that we have today of protecting against haemophilic synovitis and arthropathy of the ankle joint.
放射性滑膜切除术是一种非常有效的治疗方法,可降低与踝关节滑膜炎相关的复发性踝关节出血的频率和强度。该手术应尽快进行,以尽量减少关节软骨损伤的程度。它也可用于有抑制剂的患者,并发症风险极小。平均而言,该手术的有效率在76%至80%之间,可在任何年龄进行。该手术可减缓关节内血液长期倾向于产生的软骨损伤。在全球使用放射性滑膜切除术30年后,尚未有与放射性物质相关的损害报告。当有放射性物质时,放射性滑膜切除术目前是首选的治疗方法;然而,如果没有放射性物质,化学滑膜切除术是一种有效的替代方法。个人经验以及骨科医生和血液学家的一般建议是,当连续三次早期滑膜切除术(每3个月重复一次)未能阻止滑膜炎时,应立即考虑手术滑膜切除术(开放或关节镜下)。对于晚期踝关节血友病性关节病,最佳解决方案是踝关节融合术。一级预防和放射性滑膜切除术是我们目前预防踝关节血友病性滑膜炎和关节病的最佳方法。