Vesterager P
Scand J Clin Lab Invest Suppl. 1977;146:27-30.
Measurements of pO2 on the skin surface (tc-pO2) by means of a conventional Clark electrode have under normal conditions (i.e., without producing hyperaemia) shown low tc-pO2 values and thereby indicated only a small exchange of oxygen through the skin. By using a heated Clark electrode specially designed for application on the surface of the skin it is, however, possible to perform continuous, non-invasive monitoring of tc-pO2 which is highly correlated to the arterial pO2 (pO2 (aB)) and which responds rapidly to changes in the inspired oxygen concentration (pO2 (I)). The tc-pO2 electrode developed by Radiometer and based on the above mentioned principles, viz.: --the use of a Clark oxygen electrode --the application of hyperthermia to produce local hyperaemia is described together with the Radiometer TCM1 TC OXYGEN MONITOR. The in vitro calibration of the electrode is performed at 43 degrees C using water saturated with atmospheric air as high calibrating standard, and a sulphite solution as zero standard. The response time of the electrode lies within the range 12-18 sec for 95% response when using a 25 mu Teflon (FEP) membrane. If the calibration is performed as described, the electrode will respond almost linearly to pO2 values up to 700 mmHg.
在正常情况下(即不产生充血),使用传统的克拉克电极测量皮肤表面的氧分压(tc-pO2),结果显示tc-pO2值较低,这表明通过皮肤的氧交换量很少。然而,使用专门设计用于皮肤表面的加热克拉克电极,可以对tc-pO2进行连续、非侵入性监测,该值与动脉血氧分压(pO2(aB))高度相关,并且对吸入氧浓度(pO2(I))的变化反应迅速。由Radiometer公司研发的基于上述原理的tc-pO2电极,即:使用克拉克氧电极;应用热疗产生局部充血,将与Radiometer TCM1 TC氧监测仪一起进行描述。电极的体外校准在43摄氏度下进行,使用饱和了大气空气的水作为高校准标准,亚硫酸盐溶液作为零标准。当使用25微米的聚四氟乙烯(FEP)膜时,电极的响应时间在12至18秒范围内,95%的响应时间在此区间。如果按照所述进行校准,电极对高达700 mmHg的pO2值几乎呈线性响应。