用D因子对小鼠进行被动免疫可阻断内毒素血症期间的致死性和细胞因子释放。
Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia.
作者信息
Block M I, Berg M, McNamara M J, Norton J A, Fraker D L, Alexander H R
机构信息
Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1993 Sep 1;178(3):1085-90. doi: 10.1084/jem.178.3.1085.
Abstract
D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon gamma were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.
摘要
D因子，也称为白血病抑制因子，是一种多效性细胞因子，其在急性损伤和炎症过程中的作用尚不清楚。腹腔注射大肠杆菌内毒素可诱导小鼠D因子基因表达，而对D因子进行被动免疫可保护小鼠免受内毒素的致死作用，并阻止内毒素诱导的血清白细胞介素1和6水平升高。肿瘤坏死因子和干扰素γ的峰值水平不受影响。这些结果表明，D因子是炎症细胞因子反应的重要早期介质，因此可能在许多炎症性疾病（如败血症、关节炎、同种异体移植排斥反应和癌症免疫治疗）的发病机制中起重要作用。
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