分化因子/白血病抑制因子对小鼠致死性内毒素血症的保护作用：与白细胞介素1和肿瘤坏死因子的协同效应
Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: synergistic effect with interleukin 1 and tumor necrosis factor.
作者信息
Alexander H R, Wong G G, Doherty G M, Venzon D J, Fraker D L, Norton J A
机构信息
Surgical Metabolism Section, National Cancer Institute, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1992 Apr 1;175(4):1139-42. doi: 10.1084/jem.175.4.1139.
Abstract
Differentiation factor (D factor), also called leukemia inhibitory factor (LIF), is a glycoprotein that has been increasingly recognized to possess a wide range of physiological activities. We examined the possibility that the administration of D factor may confer beneficial effects and enhance host resistance against lethal endotoxemia. A single intravenous dose of recombinant human D factor completely protected C57/Bl6 mice from the lethal effect of Escherichia coli endotoxin (lipopolysaccharide [LPS]). The protective effects were dose dependent and observed when administered 2-24 h before LPS. Previous work has shown that interleukin 1 (IL-1) and tumor necrosis factor (TNF) also protect against a subsequent LPS challenge in a dose-dependent manner. When human D factor was combined with sub-protective doses of IL-1 beta or TNF-alpha, there was dramatic synergistic protection against a subsequent lethal LPS challenge.
摘要
分化因子（D因子），也称为白血病抑制因子（LIF），是一种糖蛋白，其具有广泛生理活性这一点已得到越来越多的认可。我们研究了给予D因子可能产生有益作用并增强宿主对致死性内毒素血症抵抗力的可能性。单次静脉注射重组人D因子可使C57/Bl6小鼠完全免受大肠杆菌内毒素（脂多糖[LPS]）的致死作用。保护作用呈剂量依赖性，且在LPS注射前2 - 24小时给药时可观察到。先前的研究表明，白细胞介素1（IL - 1）和肿瘤坏死因子（TNF）也以剂量依赖性方式保护机体免受后续LPS攻击。当人D因子与亚保护剂量的IL - 1β或TNF - α联合使用时，对后续致死性LPS攻击具有显著的协同保护作用。
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