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海兔胺素I、II和III的结构；源自加勒比海绵柱状海兔的新型溴酪氨酸衍生生物碱。

The structures of aplysinamisines I, II, and III; new bromotyrosine-derived alkaloids from the Caribbean sponge Aplysina cauliformis.

作者信息

Rodríguez A D, Piña I C

机构信息

Department of Chemistry, University of Puerto Rico, Río Piedras 00931-3346.

出版信息

J Nat Prod. 1993 Jun;56(6):907-14. doi: 10.1021/np50096a014.

DOI:10.1021/np50096a014
PMID:8350091
Abstract

Three new bromotyrosine-derived alkaloids, aplysinamisines I [4], II [5], and III [6], were isolated from the sponge Aplysina cauliformis collected in Puerto Rico and their chemical structures elucidated on the basis of spectroscopic methods. Compounds 4-6 showed marginal antimicrobial activity, and aplysinamisines II [5] and III [6] displayed modest cytotoxicity.

摘要

从在波多黎各采集的海绵状钙质软海绵中分离出三种新的溴酪氨酸衍生生物碱，即软海绵胺I [4]、II [5]和III [6]，并通过光谱方法阐明了它们的化学结构。化合物4-6显示出微弱的抗菌活性，软海绵胺II [5]和III [6]表现出适度的细胞毒性。

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