左旋多巴成功治疗儿童期起病的症状性肌张力障碍。
Successful treatment of childhood onset symptomatic dystonia with levodopa.
作者信息
Fletcher N A, Thompson P D, Scadding J W, Marsden C D
机构信息
University Department of Clinical Neurology, Institute of Neurology, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):865-7. doi: 10.1136/jnnp.56.8.865.
Three patients with childhood onset symptomatic dystonia responded to levodopa. None fulfilled criteria for a diagnosis of "dopa responsive dystonia" (Segawa's disease). One may have had athetoid cerebral palsy for almost 25 years. All obtained dramatic and sustained benefit from levodopa therapy. A therapeutic trial of levodopa is advised in all patients in whom dystonia has developed in childhood or early adult life, regardless of suspected aetiology or duration of symptoms.
三名儿童期起病的症状性肌张力障碍患者对左旋多巴有反应。无一例符合“多巴反应性肌张力障碍”（Segawa病）的诊断标准。其中一名患者可能患手足徐动型脑瘫近25年。所有患者均从左旋多巴治疗中获得显著且持续的益处。建议对所有在儿童期或成年早期出现肌张力障碍的患者进行左旋多巴治疗试验，无论其疑似病因或症状持续时间如何。
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