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治疗肌张力障碍的策略。

Treatment strategies for dystonia.

机构信息

Emory University, Department of Neurology, 1841 Clifton Road NE, Room 329, Atlanta, GA 30029, USA.

出版信息

Expert Opin Pharmacother. 2010 Jan;11(1):5-15. doi: 10.1517/14656560903426171.

Abstract

IMPORTANCE OF THE FIELD

Dystonia is a neurological syndrome characterized by involuntary twisting movements and unnatural postures. It has many different manifestations and causes, and many different treatment options are available. These options include physical and occupational therapy, oral medications, intramuscular injection of botulinum toxins, and neurosurgical interventions.

AREAS COVERED IN THIS REVIEW

In this review, we first summarize the treatment options available, then we provide suggestions from our own experience for how these can be applied in different types of dystonia. In preparing this review article, an extensive literature search was undertaken using PubMed. Only selected references from 1970 to 2008 are cited.

WHAT THE READER WILL GAIN

This review is intended to provide the clinician with a practical guide to the treatment of dystonia.

TAKE HOME MESSAGE

Treatment of dystonia begins with proper diagnosis and classification, followed by an appropriate search for underlying etiology, and an assessment of the functional impairment associated with the dystonia. The therapeutic approach, which is usually limited to symptomatic therapy, must then be tailored to the individual needs of the patient.

摘要

重要性领域

肌张力障碍是一种以不自主扭曲运动和异常姿势为特征的神经系统综合征。它有许多不同的表现形式和原因,也有许多不同的治疗选择。这些选择包括物理和职业治疗、口服药物、肌肉内注射肉毒毒素和神经外科干预。

本篇综述涵盖的内容

在这篇综述中,我们首先总结了现有的治疗选择,然后根据我们的经验,就如何将这些选择应用于不同类型的肌张力障碍提出了建议。在准备这篇综述文章时,我们使用 PubMed 进行了广泛的文献检索。只引用了 1970 年至 2008 年的精选参考文献。

读者将获得什么

这篇综述旨在为临床医生提供肌张力障碍治疗的实用指南。

重要信息

肌张力障碍的治疗始于正确的诊断和分类,然后寻找潜在病因,并评估与肌张力障碍相关的功能障碍。治疗方法通常仅限于对症治疗,然后必须根据患者的个体需求进行调整。

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本文引用的文献

1
Treatment of focal dystonias with botulinum neurotoxin.肉毒杆菌神经毒素治疗局灶性肌张力障碍
Toxicon. 2009 Oct;54(5):628-33. doi: 10.1016/j.toxicon.2008.12.008. Epub 2008 Dec 13.
3
Treatment of dystonia with deep brain stimulation.深部脑刺激治疗肌张力障碍
Neurotherapeutics. 2008 Apr;5(2):320-30. doi: 10.1016/j.nurt.2008.01.002.
4
Experimental therapeutics for dystonia.肌张力障碍的实验性治疗方法。
Neurotherapeutics. 2008 Apr;5(2):198-209. doi: 10.1016/j.nurt.2008.01.001.

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