Reynolds D L, Torrance G W, Badley E M, Bennett K J, Chambers L W, Goldsmith C H, Jamieson E, Tugwell P, Wolfson M C
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
J Rheumatol. 1993 Jun;20(6):1037-47.
A model adjusting for reductions in quality and quantity of life was developed to estimate the population health impact of musculoskeletal diseases.
Using arthritis as the prototype, prevalence, mortality, and severity data from a variety of sources were combined to model a hypothetical cohort of 1,000 individuals through life. Quality adjusted life years and population health expectancy were calculated for those with arthritis and compared to the general population.
Without adjusting for quality of life, a cohort of 1,000 women and 1,000 men at age 15 years could expect 65,010 and 58,735 life years, respectively. Adjusting for quality of life, women with arthritis could expect 61,719 life years, and men 57,123 life years. The unadjusted population health expectancy was 65.0 for girls and 58.7 for boys (at age 15 years). Adjusting for quality of life, the population health expectancies were 61.7 and 57.1, years for women and men, respectively.
Using this model, the typical adult woman with arthritis can expect to lose 3.3 healthy years of life, and a man, 1.6 healthy years of life. Overall, the model provided a general methodology for determining the population health impact of musculoskeletal diseases. In addition, it is hoped that the methodology will stimulate further research into this area, raise awareness about the uses and limitations of currently available data, and provide a useful model for monitoring the impact of interventions.
开发一个针对生活质量和数量下降进行调整的模型，以估计肌肉骨骼疾病对人群健康的影响。
以关节炎为原型，整合来自各种来源的患病率、死亡率和严重程度数据，对1000名个体的假设队列进行终生建模。计算关节炎患者的质量调整生命年和人群健康预期寿命，并与普通人群进行比较。
在不考虑生活质量的情况下，15岁的1000名女性和1000名男性队列分别预期有65010和58735个生命年。考虑生活质量后，患有关节炎的女性预期有61719个生命年，男性为57123个生命年。未调整的人群健康预期寿命在15岁女孩中为65.0岁，男孩中为58.7岁。考虑生活质量后，女性和男性的人群健康预期寿命分别为61.7岁和57.1岁。
使用该模型，患有关节炎的成年女性平均会损失3.3个健康生命年，男性为1.6个健康生命年。总体而言，该模型提供了一种确定肌肉骨骼疾病对人群健康影响的通用方法。此外，希望该方法能激发对该领域的进一步研究，提高对现有数据用途和局限性的认识，并为监测干预措施的影响提供有用的模型。
