小鼠微小病毒（MVM）的主要衣壳蛋白VP2可形成颗粒，这些颗粒能与MVM复制型DNA的3'末端发夹结构结合，并包装单链病毒子代DNA。
The major capsid protein VP2 of minute virus of mice (MVM) can form particles which bind to the 3'-terminal hairpin of MVM replicative-form DNA and package single-stranded viral progeny DNA.
作者信息
Willwand K, Hirt B
机构信息
Swiss Institute for Experimental Cancer Research, Epalinges.
出版信息
J Virol. 1993 Sep;67(9):5660-3. doi: 10.1128/JVI.67.9.5660-5663.1993.
Abstract
The capsids of minute virus of mice (MVM) consist of two closely related proteins, VP1 and VP2. We inactivated the VP1 gene in an infectious clone of MVM DNA by frameshift mutation. After transfection of mutated DNA, capsids consisting of VP2 only were made. They can package negative-strand DNA, and they specifically bind MVM 3'-terminal hairpin DNA.
摘要
小鼠微小病毒（MVM）的衣壳由两种密切相关的蛋白质VP1和VP2组成。我们通过移码突变使MVM DNA感染性克隆中的VP1基因失活。转染突变DNA后，形成了仅由VP2组成的衣壳。它们可以包装负链DNA，并且特异性结合MVM 3'-末端发夹DNA。
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