Parrish C R, Aquadro C F, Carmichael L E
James A. Baker Institute, New York State College of Veterinary Medicine, Ithaca.
Virology. 1988 Oct;166(2):293-307. doi: 10.1016/0042-6822(88)90500-4.
Canine parvovirus (CPV) is a recently recognized pathogen of dogs that is similar to the long-recognized feline, mink, and raccoon parvoviruses. Relationships between the viruses determined from DNA sequences of the capsid protein genes of 10 virus isolates showed the CPV isolates to be closely related to the other viruses, although comprising a distinct group. No immediate ancestor of CPV was observed amongst the mink, cat, or raccoon viruses examined. Three different directly repeated sequences were present within the noncoding region downstream from the capsid protein genes. Analysis of recombinants between CPV and feline panleukopenia virus at restriction sites within the capsid protein genes mapped a CPV-specific neutralization epitope on the virus capsid, differences in the pH dependence of hemagglutination, and part of the determinant of canine host range between 59 and 64 genome map units (m.u.). Those differences were therefore the result of up to three nucleotide or predicted amino acid sequence differences in that region. A second region between 64 and 73 m.u., which may affect the viability of certain recombinant viruses, contained four nucleotide differences, one of which was a coding change.
犬细小病毒（CPV）是一种最近才被认识的犬类病原体，它与早已被认识的猫细小病毒、水貂细小病毒和浣熊细小病毒相似。根据10株病毒分离株的衣壳蛋白基因DNA序列确定的病毒之间的关系表明，CPV分离株与其他病毒密切相关，尽管它们构成一个独特的群体。在所检测的水貂、猫或浣熊病毒中未观察到CPV的直接祖先。在衣壳蛋白基因下游的非编码区内存在三种不同的直接重复序列。对CPV和猫泛白细胞减少症病毒在衣壳蛋白基因内限制位点处的重组体分析，在病毒衣壳上定位了一个CPV特异性中和表位、血凝反应pH依赖性的差异以及犬宿主范围决定因素的一部分，位于基因组图谱的59至64个图谱单位（m.u.）之间。因此，这些差异是该区域最多三个核苷酸或预测氨基酸序列差异的结果。在64至73 m.u.之间的第二个区域可能影响某些重组病毒的生存能力，该区域包含四个核苷酸差异，其中一个是编码变化。
