混合表型小鼠白血病
Mixed phenotype murine leukemias.
作者信息
Defresne M P, Borremans B, Verhofstede C, Peled A, Thiry A, Greimers R, Robberecht P, Nabarra B, Verschaeve L, Hooghe R
机构信息
Laboratory of Pathological Anatomy and Cytopathology, University of Liège, Sart Tilman, Belgium.
出版信息
Leukemia. 1993 Aug;7(8):1253-60.
Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed phenotype with myeloid cytochemical markers, pre-B surface antigens and molecular markers of pro-B lymphocytes. They represent murine models for mixed phenotype (pro-pre-B-myeloid) leukemias.
细胞系源自NFS小鼠经X射线诱导产生的8种个体白血病。最初被鉴定为空细胞（表面免疫球蛋白阴性，Thy-1阴性），结果发现它们具有混合表型，带有髓系细胞化学标志物、前B细胞表面抗原和前B淋巴细胞的分子标志物。它们代表了混合表型（前体-前B-髓系）白血病的小鼠模型。
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