Henkelman R M, Huang X, Xiang Q S, Stanisz G J, Swanson S D, Bronskill M J
Sunybrook Health Science Centre, University of Toronto, Ontario, Canada.
Magn Reson Med. 1993 Jun;29(6):759-66. doi: 10.1002/mrm.1910290607.
Magnetization transfer contrast (MTC) experiments using off-resonance irradiation have been performed with an agar gel model by systematically varying offset frequency, amplitude of the RF irradiation and gel concentration. The experimental results are shown to be quantitatively modelled by a two-pool system consisting of a liquid pool with a Lorentzian line shape and a small semisolid pool with a Gaussian lineshape. The fitted model yields physically realistic fundamental parameters with a T2 of the semisolid pool of 13 microseconds. Further analysis shows that the off-resonance irradiation MTC experiment had significant limitations in its ability to saturate the semisolid pool without directly affecting the liquid component.
利用失谐辐照进行的磁化传递对比（MTC）实验，已在琼脂凝胶模型上通过系统改变失谐频率、射频辐照幅度和凝胶浓度来开展。实验结果表明，可由一个双池系统进行定量建模，该系统由具有洛伦兹线形的液体池和具有高斯线形的小半固体池组成。拟合模型得出了物理上现实的基本参数，半固体池的T2为13微秒。进一步分析表明，失谐辐照MTC实验在不直接影响液体成分的情况下饱和半固体池的能力存在显著局限性。
