Saturation transfer MR fingerprinting for magnetization transfer contrast and chemical exchange saturation transfer quantification.

PURPOSE

The aim of this study was to develop a saturation transfer MR fingerprinting (ST-MRF) technique using a biophysics model-driven deep learning approach.

METHODS

A deep learning-based quantitative saturation transfer framework was proposed to estimate water, magnetization transfer contrast, and amide proton transfer (APT) parameters plus B field inhomogeneity. This framework incorporated a Bloch-McConnell simulator during neural network training and enforced consistency between synthesized MRF signals and experimentally acquired ST-MRF signals. Ground-truth numerical phantoms were used to assess the accuracy of estimated tissue parameters, and in vivo tissue parameters were validated using synthetic MRI analysis.

RESULTS

The proposed ST-MRF reconstruction network achieved a normalized root mean square error (nRMSE) of 9.3% when tested against numerical phantoms with a signal-to-noise ratio of 46 dB, which outperformed conventional Bloch-McConnell fitting (nRMSE of 15.3%) and dictionary-matching approaches (nRMSE of 19.5%). Synthetic MRI analysis indicated excellent similarity (RMSE = 3.2%) between acquired and synthesized ST-MRF images, demonstrating high in vivo reconstruction accuracy. In healthy human brains, the APT pool size ratios for gray and white matter were 0.16 ± 0.02% and 0.13 ± 0.02%, respectively, and the exchange rates for gray and white matter were 101 ± 25 Hz and 131 ± 27 Hz, respectively. The reconstruction network processed the eight tissue parameter maps in approximately 27 s for ST-MRF data sized at 256 × 256 × 9 × 103.

CONCLUSION

This study highlights the feasibility of the deep learning-based ST-MRF imaging for rapid and accurate quantification of free bulk water, magnetization transfer contrast, APT parameters, and B field inhomogeneity.