Azuma Y, Kawamura K, Isogai H, Isogai E
Monami Animal Clinic, Hokkaido, Japan.
Microbiol Immunol. 1993;37(4):325-9. doi: 10.1111/j.1348-0421.1993.tb03217.x.
A 2-year-old mongrel dog developed neurological signs following tick bite. These included astasia, persistent tonic convulsions and hyper-reflexia. Both serum IgG and IgM antibody titers against Borrelia burgdorferi were positive in enzyme-linked immunosorbent assay (ELISA). The neurological signs subsided after high-dose penicillin and streptomycin treatment. A strain of spirochetes (P427a) was isolated from the midgut of Ixodes persulcatus feeding on the dog. Morphological characteristic, immunological property and protein profile revealed that the isolate was B. burgdorferi. Similarly, a 2-year-old Labrador retriever dog developed neurological signs after tick bite and showed a positive IgG antibody titer against B. burgdorferi. Antibiotic treatment was effective also in this case. These findings suggest that neurological symptoms shown in both dogs were caused by infection with B. burgdorferi.
一只2岁的杂种犬在被蜱叮咬后出现神经症状。这些症状包括站立不能、持续性强直性惊厥和反射亢进。在酶联免疫吸附测定（ELISA）中，针对伯氏疏螺旋体的血清IgG和IgM抗体效价均为阳性。经大剂量青霉素和链霉素治疗后，神经症状消退。从叮咬该犬的全沟硬蜱中肠分离出一株螺旋体（P427a）。形态特征、免疫学特性和蛋白质谱显示该分离株为伯氏疏螺旋体。同样，一只2岁的拉布拉多猎犬在被蜱叮咬后出现神经症状，并且针对伯氏疏螺旋体的IgG抗体效价呈阳性。抗生素治疗在该病例中也有效。这些发现表明，两只犬所表现出的神经症状是由伯氏疏螺旋体感染引起的。
